For their biological activity, estrogens are used to stimulate the myometrial muscular tone, cause regression of the persistent corpus luteum, and improve the function of the corpus luteum in the sows causing relaxing of the cervix and in the treatment of the following conditions, accompanied by antibiotic therapy metritis, pyometra, aid in the expulsion of mummified or macerated fetuses, retained placenta and uterine exudates, is effective in the treatment of uterine incontinence and at the end of the period of pseudopregnancy, to relieve the congestion of the udder in female dogs. lndicated in therapeutic abortion for domestic animals